Is it important for older adults to build a trusting relationship with their physician and how is this affected by their personality and mood? Personality pathology (PP) has been tied to both mental and physical health in older adulthood. The present study explored the relationships between personality, mood, and trust in physicians. A sample (N = 170) of medical outpatient older adults between the ages of 60 and 99 completed self-report measures of personality traits (NEO—five factor inventory, NEO-FFI) and processes (Inventory of Interpersonal Problems-Personality Disorder, IIP-PD-25), depression (Geriatric Depression Scale, GDS-30), social role impairment (Social Adjustment Scale—Self Report, SAS-SR), and general trust in physicians (General Trust in Physicians Scale, GTIPS). Cumulative illness burden data (Cumulative Illness Rating Scale, CIRS) were retrieved from medical records. PP and trust independently predicted outcomes. In separate models, higher neuroticism, lower agreeableness, more interpersonal problems, and lower trust predicted depression. In combined models, higher neuroticism and lower trust predicted depression, and higher neuroticism and interpersonal problems predicted impaired social functioning. Trust did not moderate the relationship between PP and depression or social functioning impairment. The present findings regarding lower levels of trust and increased self-reported depression are particularly relevant for the older adult population, as they interact with health care professionals on a regular basis. Associations between trust in physicians and self-reported depression have implications for both the assessment and treatment of depressed older adults. (PsycInfo Database Record (c) 2022 APA, all rights reserved)