Background: The first year of university is a transition period in which the problem of adjustment represents a marker of success but also of letting go. This longitudinal study seeks to analyze the psychological adjustment of first year university with regard to basic psychological needs satisfaction and frustration. Method: The sample consists of 247 students (Mage = 18.42; SDage = 0.64; 84.61% female). Results: A longitudinal cluster analysis revealed a diversity of adjustment expression forms over time. Repeated variance analysis measures identified specific profiles in consideration of basic psychological needs satisfaction and frustration. Conclusion: The results emphasize that reducing needs frustration represents a possible driver of action to encourage positive psychological adjustment in a university context. (PsycInfo Database Record (c) 2022 APA, all rights reserved)