To better understand the psychological well-being of Asian Americans living in the U.S., the present study focused on the experience of acculturative stress, family cohesion, and depression among Asian American immigrants (n = 1,641). Drawing data from the National Latino and Asian American Study (NLAAS), one of the first national epidemiological studies of Asian American’s mental health, this study examined the associations between acculturative stress, family cohesion, and depression. In addition to correlation analyses, a logistic regression analysis was conducted to examine the potential buffering effect of family cohesion on the association between acculturative stress and depression. The results revealed that although family cohesion as a moderator was not found to be statistically significant, direct effects between acculturative stress and depression, and family cohesion and depression were both found to be significant. Both clinical and theoretical implications are discussed. (PsycInfo Database Record (c) 2022 APA, all rights reserved)