Recent advancements in video telehealth technology have increased access to specialty services for Veterans with posttraumatic stress disorder (PTSD) who could not otherwise attend therapy due to geographic and economic constraints. While previous literature has indicated comparable symptom reduction outcomes for in-person and telehealth care, recent findings from the 2019 J. D. Power U.S. Telehealth Satisfaction Study found Veteran apprehension about the perceived effectiveness of telehealth treatment. To address this, the present study compared the effects of prolonged exposure (PE) and cognitive processing therapy (CPT) on symptoms of PTSD and depression across in-person, clinic-to-clinic telehealth, or home-based telehealth delivery for a sample of Veterans. The study used a retrospective cohort design. Data were collected from 581 Veterans located within the Fargo Veterans Affairs (VA) Health Care System catchment area of the Veterans Integrated Service Network (VISN) 23, one of the most rural VISN areas in the nation, who initiated PTSD treatment between January 2017 and February 2020. Results showed significant reductions in symptoms of PTSD and depression for Veterans completing a full course of PE or CPT, regardless of treatment delivery modality. Overall findings suggested that PE and CPT, when delivered across any format, could produce satisfactory outcomes for Veterans living in rural areas. (PsycInfo Database Record (c) 2021 APA, all rights reserved)