Despite the relative ubiquity of marriage, the quality of marital relationships has varied significantly over time and across cultures. Although research has shown both compassion and values predict marital quality, researchers remain unclear how these constructs interact to impact marital quality. The purpose of the study described in this article was to explore how self-transcendent other-focused values and compassion impact marital quality across regional contexts in the United States. Study participants (n = 1,513) living in Arkansas, Utah, and Vermont in 2013 completed a self-report telephone survey. In an effort to mitigate potential response bias and impression management, participants were asked to rate their spouse’s values and compassion and to report their own marital quality. In the overall sample, compassion and self-transcendent values explained 28% of the variance in marital quality. However, there were differences observed in the predictive potential of compassion and self-transcendent values between regions in the United States. Specifically, these variables accounted for 19% of the variance in marital quality in Arkansas, and for 32% in Utah and Vermont. Relatedly, when a partner’s perceived self-transcendent values were lower, compassion was more important in promoting marital quality. This provides some evidence for regional and cultural differences and points to compassion as a behavioral function of deeply held values. (PsycInfo Database Record (c) 2020 APA, all rights reserved)