This article reviews research exploring the interface of stress and infertility, attempting to answer the following questions: Does infertility cause stress? Does stress impact fertility? Does infertility treatment cause stress? Does stress impact treatment outcomes? Can stress reduction effect treatment distress and outcomes? Is there residual stress after treatment? Recommendations are made to mental health professionals to help their infertile patients cope more effectively with infertility stress, and suggestions are offered for future research directions. (PsycINFO Database Record (c) 2018 APA, all rights reserved)