Journal of Systemic Therapies 30(1): 1-13 This article reviews some of the recent advances in brain research and the growing field of interpersonal neurobiology, which we believe supports a number of narrative therapy premises. Highlighted is the potential usefulness of thinking about unique outcomes as moments of affect-infused experiences. The concepts and theory proposed are illustrated by the description of three therapy sessions with a 28-year-old woman struggling with anxiety and depression, and a transcript of an intentionally affect infused re-authoring conversation.