This article challenges the idea that mixed methods research (MMR) constitutes a coherent research paradigm and explores how different research paradigms exist within MMR. Tracing paradigmatic differences at the level of methods, ontology, and epistemology, two MMR strategies are discussed: nested analysis, recently presented by the American political scientist Evan S. Lieberman, and praxeological knowledge, inspired by the French sociologist Pierre Bourdieu. These strategies address two different epistemological problems, namely, the problem of causal inference and the problem of double hermeneutics. Consequently, the research designs as well as the understandings of the “qualitative component” differ noticeably. Realizing such differences at the ontological, epistemological, and methodological level contributes to discussions on how to move forward MMR, embracing differences instead of imposing homogeneity.