Abstract
Although family history of prostate cancer (PC) is an established risk factor for the disease, few studies have investigated
this relationship among men with an African heritage. The Prostate Cancer in a Black Population (PCBP) study is a large, nationwide
case–control study conducted in Barbados, West Indies from 2002 to 2011. In the PCBP study, a family history of PC in fathers
or brothers was associated with a threefold increased risk of disease (OR = 3.04, 95 % CI (2.18, 4.22)) and a strong positive
relationship was noted for the number of affected first degree relatives. Tumor grade did not generally influence the relationship
between family history and PC. The magnitude of risks associated with having a father affected with the disease was slightly
higher in the PCBP study compared to other populations. It remains unclear whether this finding is the result of an increased
genetic susceptibility in African-Barbadian men.
this relationship among men with an African heritage. The Prostate Cancer in a Black Population (PCBP) study is a large, nationwide
case–control study conducted in Barbados, West Indies from 2002 to 2011. In the PCBP study, a family history of PC in fathers
or brothers was associated with a threefold increased risk of disease (OR = 3.04, 95 % CI (2.18, 4.22)) and a strong positive
relationship was noted for the number of affected first degree relatives. Tumor grade did not generally influence the relationship
between family history and PC. The magnitude of risks associated with having a father affected with the disease was slightly
higher in the PCBP study compared to other populations. It remains unclear whether this finding is the result of an increased
genetic susceptibility in African-Barbadian men.
- Content Type Journal Article
- Category Original Paper
- Pages 1-6
- DOI 10.1007/s10903-012-9710-7
- Authors
- Barbara Nemesure, Department of Preventive Medicine, Stony Brook Medicine, Stony Brook, NY 11794-8036, USA
- Suh-Yuh Wu, Department of Preventive Medicine, Stony Brook Medicine, Stony Brook, NY 11794-8036, USA
- Anselm Hennis, Department of Preventive Medicine, Stony Brook Medicine, Stony Brook, NY 11794-8036, USA
- M. Cristina Leske, Department of Preventive Medicine, Stony Brook Medicine, Stony Brook, NY 11794-8036, USA
- Journal Journal of Immigrant and Minority Health
- Online ISSN 1557-1920
- Print ISSN 1557-1912