Abstract
While performance-based tests of everyday functioning offer promise in facilitating diagnosis and classification of HIV-associated
neurocognitive disorders (HAND), there remains a dearth of well-validated instruments. In the present study, clinical correlates
of performance on one such measure (i.e., Medication Management Test—Revised; MMT-R) were examined in 448 HIV+ adults who
were prescribed antiretroviral therapy. Significant bivariate relationships were found between MMT-R scores and demographics
(e.g., education), hepatitis C co-infection, estimated premorbid IQ, neuropsychological functioning, and practical work abilities.
MMT-R scores were not related to HIV disease severity, psychiatric factors, or self-reported adherence among participants
with a broad range of current health status. However, lower MMT-R scores were strongly and uniquely associated with poorer
adherence among participants with CD4 T cell counts <200. In multivariate analyses, MMT-R scores were predicted by practical
work abilities, estimated premorbid functioning, attention/working memory, learning, and education. Findings provide overall
mixed support for the construct validity of the MMT-R and are discussed in the context of their clinical and research implications
for evaluation of HAND.
neurocognitive disorders (HAND), there remains a dearth of well-validated instruments. In the present study, clinical correlates
of performance on one such measure (i.e., Medication Management Test—Revised; MMT-R) were examined in 448 HIV+ adults who
were prescribed antiretroviral therapy. Significant bivariate relationships were found between MMT-R scores and demographics
(e.g., education), hepatitis C co-infection, estimated premorbid IQ, neuropsychological functioning, and practical work abilities.
MMT-R scores were not related to HIV disease severity, psychiatric factors, or self-reported adherence among participants
with a broad range of current health status. However, lower MMT-R scores were strongly and uniquely associated with poorer
adherence among participants with CD4 T cell counts <200. In multivariate analyses, MMT-R scores were predicted by practical
work abilities, estimated premorbid functioning, attention/working memory, learning, and education. Findings provide overall
mixed support for the construct validity of the MMT-R and are discussed in the context of their clinical and research implications
for evaluation of HAND.
- Content Type Journal Article
- Category Original Paper
- Pages 1-11
- DOI 10.1007/s10461-012-0237-7
- Authors
- Doyle E. Patton, Children’s Diagnostic & Treatment Center, 1401 South Federal Highway, Fort Lauderdale, FL 33316, USA
- Steven Paul Woods, Department of Psychiatry, University of California, San Diego, USA
- Donald Franklin Jr., Department of Psychiatry, University of California, San Diego, USA
- Jordan E. Cattie, Clinical Psychology, San Diego State University and University of California, San Diego, USA
- Robert K. Heaton, Department of Psychiatry, University of California, San Diego, USA
- Ann C. Collier, Harborview Medical Center and University of Washington, Seattle, WA, USA
- Christina Marra, Harborview Medical Center and University of Washington, Seattle, WA, USA
- David Clifford, Neuroscience Center, Washington University, St. Louis, MO, USA
- Benjamin Gelman, Department of Pathology, University of Texas, Medical Branch, Galveston, TX, USA
- Justin McArthur, Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
- Susan Morgello, Department of Pathology, Mount Sinai School of Medicine, New York, NY, USA
- David Simpson, Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA
- J. Allen McCutchan, Department of Psychiatry, University of California, San Diego, USA
- Igor Grant, Department of Psychiatry, University of California, San Diego, USA
- Journal AIDS and Behavior
- Online ISSN 1573-3254
- Print ISSN 1090-7165