The efficacy of a computer-based intervention to increase parent-adolescent communication among Latino parents and adolescents was tested in a randomized controlled trial. Parents assigned to receive the 2-session intervention reported greater general communication, sexual communication, and comfort with communication at 3-month follow-up than did parents assigned to the wait-list control condition. Adolescents whose parents received the intervention reported higher sexual communication than did adolescents whose parents were in the wait-list control condition. Results provide support for the efficacy of brief parent interventions designed to maximize adolescent support systems. The acceptability of the computer-based format for an underserved population provides an important venue for the delivery and use of health information.