Abstract
Purpose
The psychometric properties of a health-related quality of life (HRQOL) instrument, the Cystic Fibrosis Questionnaire-Revised
(CFQ-R), were evaluated in a national, US sample of patients with cystic fibrosis (CF). This is the first psychometric evaluation
of the revised version of this instrument.
(CFQ-R), were evaluated in a national, US sample of patients with cystic fibrosis (CF). This is the first psychometric evaluation
of the revised version of this instrument.
Methods
The Epidemiologic Study of CF is a national, US multicenter longitudinal cohort study containing CFQ-R and health outcomes
data. Developmentally appropriate versions of the CFQ-R were available from 7,330 patients aged 6–70 years and a proxy version
from 2,728 parents of school-age children. The CFQ-R was completed during a “stable” or “sick” visit before recording health
outcomes such as weight, lung function, and pulmonary exacerbations.
data. Developmentally appropriate versions of the CFQ-R were available from 7,330 patients aged 6–70 years and a proxy version
from 2,728 parents of school-age children. The CFQ-R was completed during a “stable” or “sick” visit before recording health
outcomes such as weight, lung function, and pulmonary exacerbations.
Results
There were few floor and ceiling effects and strong internal consistency (Cronbach alpha ≥0.70) for most scales. The CFQ-R
consistently discriminated between patients seen for sick-versus-well visits, and among stages of disease severity based on
lung function. As predicted, women with CF reported worse HRQOL than men on scales not related to body image and weight. Strong
parent–child agreement was found on scales measuring observable behaviors (respiratory symptoms). Convergence between CFQ-R
scales and health outcomes provided evidence of construct validity.
consistently discriminated between patients seen for sick-versus-well visits, and among stages of disease severity based on
lung function. As predicted, women with CF reported worse HRQOL than men on scales not related to body image and weight. Strong
parent–child agreement was found on scales measuring observable behaviors (respiratory symptoms). Convergence between CFQ-R
scales and health outcomes provided evidence of construct validity.
- Content Type Journal Article
- Category Erratum
- Pages 1-12
- DOI 10.1007/s11136-011-0091-5
- Authors
- Alexandra L. Quittner, University of Miami, 5665 Ponce de Leon Blvd., Coral Gables, FL 33146, USA
- Gregory S. Sawicki, Children’s Hospital Boston, Boston, MA, USA
- Ann McMullen, University of Rochester Medical Center, Rochester, NY, USA
- Lawrence Rasouliyan, ICON Late Phase & Outcomes Research, San Francisco, CA, USA
- David J. Pasta, ICON Late Phase & Outcomes Research, San Francisco, CA, USA
- Ashley Yegin, Genentech, Inc., South San Francisco, CA, USA
- Michael W. Konstan, Rainbow Babies and Children’s Hospital and Case Western Reserve, University School of Medicine, Cleveland, OH, USA
- Journal Quality of Life Research
- Online ISSN 1573-2649
- Print ISSN 0962-9343