Abstract
Methods
Subjects enrolled in the Comprehensive Longitudinal Investigation of MS at the Brigham and Women’s Hospital with RRMS were
eligible for enrollment. Subjects with a clinical visit within 45 days of a relapse were identified and divided into groups
based on whether the relapse occurred before (recent relapse) (n = 59) or after the visit (pre-relapse) (n = 31). A group of subjects with no relapses was also identified (remission) (n = 336). PRO measures in these three groups were compared. All outcomes were compared using a t test and linear regression controlling for age, disease duration, sex, and EDSS.
eligible for enrollment. Subjects with a clinical visit within 45 days of a relapse were identified and divided into groups
based on whether the relapse occurred before (recent relapse) (n = 59) or after the visit (pre-relapse) (n = 31). A group of subjects with no relapses was also identified (remission) (n = 336). PRO measures in these three groups were compared. All outcomes were compared using a t test and linear regression controlling for age, disease duration, sex, and EDSS.
Results
Subjects with a recent relapse had significantly worse functioning on several physical and mental health scales compared to
subjects in remission even after adjusting for potential confounders. Subjects with a recent relapse also showed significant
deterioration on PRO measures over 1 year compared to subjects in remission (P < 0.05 for each comparison). Subjects in the pre-relapse group were not significantly different than subjects in remission.
subjects in remission even after adjusting for potential confounders. Subjects with a recent relapse also showed significant
deterioration on PRO measures over 1 year compared to subjects in remission (P < 0.05 for each comparison). Subjects in the pre-relapse group were not significantly different than subjects in remission.
- Content Type Journal Article
- Pages 1-8
- DOI 10.1007/s11136-011-0108-0
- Authors
- Brian C. Healy, Partners Multiple Sclerosis Center, Brigham and Women’s Hospital, 6th Floor, 1 Brookline Place, Brookline, MA 02445, USA
- Irene R. Degano, Partners Multiple Sclerosis Center, Brigham and Women’s Hospital, 6th Floor, 1 Brookline Place, Brookline, MA 02445, USA
- Ana Schreck, Partners Multiple Sclerosis Center, Brigham and Women’s Hospital, 6th Floor, 1 Brookline Place, Brookline, MA 02445, USA
- David Rintell, Partners Multiple Sclerosis Center, Brigham and Women’s Hospital, 6th Floor, 1 Brookline Place, Brookline, MA 02445, USA
- Howard Weiner, Partners Multiple Sclerosis Center, Brigham and Women’s Hospital, 6th Floor, 1 Brookline Place, Brookline, MA 02445, USA
- Tanuja Chitnis, Partners Multiple Sclerosis Center, Brigham and Women’s Hospital, 6th Floor, 1 Brookline Place, Brookline, MA 02445, USA
- Bonnie I. Glanz, Partners Multiple Sclerosis Center, Brigham and Women’s Hospital, 6th Floor, 1 Brookline Place, Brookline, MA 02445, USA
- Journal Quality of Life Research
- Online ISSN 1573-2649
- Print ISSN 0962-9343