Background:
Canada is among the most prosperous nations in the world, yet the health and wellness outcomes of Canadian children are surprisingly poor. There is some evidence to suggest that these poor health outcomes are partly due to clinical practice variation, which can stem from failure to apply the best available research evidence in clinical practice, otherwise known as knowledge translation (KT). Surprisingly, clinical practice variation, even for common acute paediatric conditions, is pervasive. Clinical practice variation results in unnecessary medical treatments, increased suffering, and increased health care costs. This study focuses on improving health outcomes for common paediatric acute health concerns by evaluating strategies that improve knowledge translation and reduce clinical practice variation.Design/Methods: Using a multiple case study design, qualitative and quantitative data will be collected from four Emergency Departments in western Canada. Data sources will include: 1) pre- and post-implementation focus group data from multidisciplinary health care professionals, 2) individual interviews with the local champions, KT intervention providers and unit/site leaders/managers, 3) Alberta Context Tool (ACT) survey data, and 4) aggregated patient outcome data. Qualitative and quantitative data will be systematically triangulated and matrices will be built to do cross-case comparison. Explanations will be built about the success or lack of success of the CPG/CPs uptake based upon the cross-case comparisons.Significance: This study will generate new knowledge about the potential causal mechanisms and factors which shape implementation. Future studies will track the impact of the CPG/CPs implementation on children’s health outcome, and healthcare costs.