Comparing higher order models for the EORTC QLQ-C30

To investigate the statistical fit of alternative higher order models for summarizing the health-related quality of life profile
generated by the EORTC QLQ-C30 questionnaire.

A 50% random sample was drawn from a dataset of more than 9,000 pre-treatment QLQ-C30 v 3.0 questionnaires completed by cancer
patients from 48 countries, differing in primary tumor site and disease stage. Building on a “standard” 14-dimensional QLQ-C30
model, confirmatory factor analysis was used to compare 6 higher order models, including a 1-dimensional (1D) model, a 2D
“symptom burden and function” model, two 2D “mental/physical” models, and two models with a “formative” (or “causal”) formulation
of “symptom burden,” and “function.”

All of the models considered had at least an “adequate” fit to the data: the less restricted the model, the better the fit.
The RMSEA fit indices for the various models ranged from 0.042 to 0.061, CFI’s 0.90–0.96, and TLI’s from 0.96 to 0.98. All
chi-square tests were significant. One of the Physical/Mental models had fit indices superior to the other models considered.

The Physical/Mental health model had the best fit of the higher order models considered, and enjoys empirical and theoretical support in comparable
instruments and applications.