The Cancer Moonshot Program aims to reduce cancer mortality by 50% within 25 years through innovation in early detection, precision medicine and novel therapies. However, achieving this goal requires an equal emphasis on supportive oncology, which addresses symptom management, psychosocial needs, and quality of life. Despite its proven benefits, supportive care remains underfunded and often delayed in cancer treatment. This editorial highlights ongoing initiatives within the Moonshot framework, such as the integration of early palliative care and the expansion of telehealth services. Challenges, including provider awareness and reimbursement barriers, must be addressed to ensure equitable, patient-centred cancer care.