This randomized controlled study was conducted to investigate effects of face-to-face education and tele-education given to individuals with atrial fibrillation (AF) taking oral anticoagulants on their medication compliance and satisfaction levels. The study sample comprised 150 individuals. Of them, 50 were assigned to the control group, 50 to experimental Group 1, and 50 to experimental Group 2. Data were collected with the Descriptive Information Form, Medication Compliance Notification Scale, and Duke Anticoagulation Satisfaction Scale (DASS). Intervention Group 1 was given face-to-face education. Intervention Group 2 was given tele-education. The control group underwent no intervention. The scales were administered to all the groups twice. Intragroup analysis demonstrated that the Medication Compliance Notification Scale score of the face-to-face education group increased significantly in the final measurement compared to those of the control group and tele-education group. Intergroup analysis demonstrated that the DASS scores of the three groups significantly differed. The difference stemmed from intervention Group 1. Face-to-face education given to individuals with AF on oral anticoagulants improved their medication compliance and medication satisfaction levels. Nurses should primarily use face-to-face education in the care and education programs of individuals with AF.