Patients with psychiatric disorders often have foreshortened lives, attributed both to “natural” medical and “unnatural” external causes of death such as suicide, homicide, and accident. Many deaths are foreseeable due to circumstances linked to patients’ psychiatric disorders. These can include illness-associated disparities, adverse treatment effects, lack of self-care, and behaviors stemming directly from psychopathological processes. Whereas some of these processes contribute indirectly to patients’ causes of death, others are more directly consequential, causing patients to “die from” their psychiatric disorders. Some patients manifest likely fatal trajectories that may lead to “end-stage” psychiatric disorders. Palliative approaches may optimize their quality of life and potentially alter these trajectories, but patients with psychiatric disorders are less likely to receive optimal end-of-life care. Although assuring a “good death” can be challenging, systematic efforts can assist in providing patients with psychiatric disorders deaths with dignity rather than indignity.