This study examines Black, Latino, Asian American, American Indian and Biracial participants’ (N = 260) emotional and psychological reactions to encounters with racism, and the help-seeking strategies they used to deal with those reactions. This class of participants is important to study because its members are likely to live and/or work in racially diverse environments. Participants who reported direct experiences with racism had higher levels of anxiety, guilt/shame, hypervigilance, and positive emotions than those who did not. Racial harassment (hostility) was associated with more hypervigilant and anxious reactions than racial discrimination (avoidance). Help-seeking patterns indicated that people of Color were more likely to seek help from friends and family than from mental health professionals. Practice and research implications are addressed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)