Abstract
Background and Objectives
Childhood trauma (CT) increases addiction vulnerability. We examined CT’s impact on delta-9-tetrahydrocannabinol (THC) effects.
Methods
This is a post-hoc analysis of a randomized, placebo-controlled, crossover trial investigating the effects of oral THC (10, 20 mg) among 25 persons receiving methadone for opioid use disorder (OUD).
Results
Greater CT was associated with lower aversive effects from higher THC doses (20 mg) (p = .006).
Discussion and Conclusions
CT may reduce the subjective aversive effects of THC, potentially leading to greater cannabis use in individuals with OUD.
Scientific Significance
These findings offer insights into THC’s risks versus benefits in OUD subgroups and emphasize assessing CT in OUD treatment and research.