Whilst it is one thing to say disablism negatively impacts the lives and well-being of people with impairments, it is another altogether to tease out how this happens in everyday life. This article explores the potential of combining sociological theories and method with a psychosocial framework as an interdisciplinary approach to studying the transitional experiences of people with impairments. Using a single life history case study of Ella, a young woman with a severe physical impairment, it clearly illustrates that the impact of disablism on transition is contextual and mediated by a combination of socio-historical factors. It highlights, in particular, the constant tension between agency and structure—revealing that Ella’s levels of personal agency to challenge or undermine disablism varied from one social con-text to another and from one life phase to the next.