In ‘Mental health outcomes of the Daily Mile in elementary school children: a single-arm pilot study’, Arkesteyn et al. (Child and Adolescent Mental Health, 2022) discussed and investigated the effect of a classroom activity break, named The Daily Mile, on pupils’ self-esteem, self-perception competence, and mental health. Starting from the interesting and novel results of Arkesteyn et al. (Child and Adolescent Mental Health, 2022), this comment focuses on the concurrent evidence about the effect of The Daily Mile on pupils’ physical and mental health. Overall, this comment would reflect and critically review considerations for future research on the topic and to adopt it in the school context.