Abstract
We piloted a suite of approaches aimed to facilitate a successful series of up to four brain and muscle 31Phosphorus-Magnetic Resonance Spectroscopy (31P-MRS) scans performed in one session in 12 awake, non-sedated subjects (ages 6–18), 6 with autism spectrum disorders (ASD) and 6 controls. We targeted advanced preparation,
parental input, physical comfort, short scan protocols, allocation of extra time, and subject emotional support. 100% of subjects
completed at least one brain scan and one leg muscle scan: 42 of 46 attempted scans were completed (91%), with failures dominated
by exercise muscle scans (completed in 6/6 controls but 3/6 cases). One completed scan lacked usable data unrelated to subject/scan
procedure (orthodonture affected a frontal brain scan). As a group, these methods provide a foundation for conduct and enhancement
of future MR studies in pediatric subjects with ASD.
parental input, physical comfort, short scan protocols, allocation of extra time, and subject emotional support. 100% of subjects
completed at least one brain scan and one leg muscle scan: 42 of 46 attempted scans were completed (91%), with failures dominated
by exercise muscle scans (completed in 6/6 controls but 3/6 cases). One completed scan lacked usable data unrelated to subject/scan
procedure (orthodonture affected a frontal brain scan). As a group, these methods provide a foundation for conduct and enhancement
of future MR studies in pediatric subjects with ASD.
- Content Type Journal Article
- Category Brief Report
- Pages 1-7
- DOI 10.1007/s10803-011-1359-x
- Authors
- Laura C. Erickson, Department of Medicine, University of California, San Diego, 9500 Gilman Dr #0995, La Jolla, CA 92093-0995, USA
- Ashley A. Scott-Van Zeeland, Department of Medicine, University of California, San Diego, 9500 Gilman Dr #0995, La Jolla, CA 92093-0995, USA
- Gavin Hamilton, Department of Radiology, University of California, San Diego, 9500 Gilman Dr #8226, La Jolla, CA 92093-8226, USA
- Alan Lincoln, Alliant International University, 10455 Pomerado Rd, San Diego, CA 92131, USA
- Beatrice A. Golomb, Department of Medicine, University of California, San Diego, 9500 Gilman Dr #0995, La Jolla, CA 92093-0995, USA
- Journal Journal of Autism and Developmental Disorders
- Online ISSN 1573-3432
- Print ISSN 0162-3257