Research suggests that career interest may originate from learning-related traits. Extending this area, this study examined (a) the effect of learning goal orientation on career interest via career self-efficacy and (b) the moderating effect of learning goal orientation on the career self-efficacy–career interest relationship. Using a sample of 178 full-time employees, this study found that career self-efficacy mediated the positive learning goal orientation–career interest relationship. Results also showed a stronger relationship between career self-efficacy and career interest for workers with stronger rather than weaker learning goal orientation. Regarding practical implications, employers may wish to initiate in-service training to enhance employees’ career interest, and career counselors could set achievable goals to strengthen clients’ interest in their career.