Immigrant farmworkers in the United States are a vulnerable population who often face uncertain legal standing, fewer financial and health‐related resources, and higher exposure to work hazards. This article focuses on the loneliness—the subjective experience of social isolation—of immigrant farmworker communities, analyzes the social patterning of loneliness in this population, and estimates its association with self‐rated health. Data come from interviews with immigrant farmworkers (N = 260) at two sites in the rural Southeast. Immigrant farmworkers report substantially high levels of loneliness and appear to be lonelier than the levels found in a diverse range of other published studies of adults. Older women immigrant farmworkers, those with no formal schooling, and farmworkers experiencing food insecurity are especially lonely, and they stand to benefit most from social service outreach. However, the association between loneliness and self‐rated health is relatively weak.