Self-regulatory Fatigue in Hematologic Malignancies: Impact on Quality of Life, Coping, and Adherence to Medical Recommendations

Hematopoietic stem cell transplantation (HSCT) is an intensive cancer therapy entailing numerous physical, emotional, cognitive,
and practical challenges. Patients’ ability to adjust and cope with such challenges may depend on their ability to exert control
over cognitive, emotional, and behavioral processes, that is, ability to self-regulate. Self-regulatory capacity is a limited
resource that can be depleted or fatigued (i.e., “self-regulatory fatigue”), particularly in the context of stressful life
events such as cancer diagnosis and treatment.

This is one of the first studies to examine self-regulatory fatigue in a cancer population. The current study aimed to (1)
extract items for a specific scale of self-regulatory capacity and (2) examine the impact of such capacity on adaptation in
patients with hematologic malignancies preparing for HSCT.

Factor analysis of four existing scales gauging psychological adjustment and well-being in 314 patients preparing for HSCT
(63% male and 89% Caucasian) identified 23 items (α = 0.85) related to self-regulatory control or fatigue. This measure was then examined using existing clinical data obtained
from 178 patients (57% male and 91% Caucasian) undergoing treatment for hematologic malignancies in relationship to quality
of life, coping, and self-reported adherence to physicians’ recommendations.

Controlling for pain severity, physical fatigue, and depression, self-regulatory fatigue scores were incrementally associated
with decreased quality of life, use of avoidance coping strategies, and decreased adherence to physicians’ recommendations.

These results emphasize the potential role of self-regulatory capacity in coping with and adjusting to hematologic cancers
and future research is warranted.