Abstract
This study sought to compare Bupropion versus Sertraline in the treatment of depressed patients with Binge Eating Disorder
(BED) prescribed off-label. Medical records of outpatients with diagnosis of BED and Depression (DSM-IV-TR criteria) were
selected: 15 patients were treated with bupropion 150 mg/per day, and 15 with sertraline 200 mg/per day. During the screening
and control visits (2°–6°–14°–24° week), the selected patients were first weighed and then evaluated using the following questionnaires:
Binge Eating Disorder-Clinical Interview (BEDCI), Beck Depression Inventory (BDI), State-Trait Anxiety Inventory X (STAI-X)
and Arizona Sexual Experience Scale (ASEX). Both drugs reduced anxious-depressive symptoms and binge frequency: Bupropion
showed a better effectiveness in reducing weight and improving sexual performances; weight loss related to it was proportional
to the body mass index. Bupropion may be associated with more weight loss in BED, depressed patients than sertraline.
(BED) prescribed off-label. Medical records of outpatients with diagnosis of BED and Depression (DSM-IV-TR criteria) were
selected: 15 patients were treated with bupropion 150 mg/per day, and 15 with sertraline 200 mg/per day. During the screening
and control visits (2°–6°–14°–24° week), the selected patients were first weighed and then evaluated using the following questionnaires:
Binge Eating Disorder-Clinical Interview (BEDCI), Beck Depression Inventory (BDI), State-Trait Anxiety Inventory X (STAI-X)
and Arizona Sexual Experience Scale (ASEX). Both drugs reduced anxious-depressive symptoms and binge frequency: Bupropion
showed a better effectiveness in reducing weight and improving sexual performances; weight loss related to it was proportional
to the body mass index. Bupropion may be associated with more weight loss in BED, depressed patients than sertraline.
- Content Type Journal Article
- Category Original Paper
- Pages 1-9
- DOI 10.1007/s11126-011-9192-0
- Authors
- Carmela Calandra, Department of Medical and Surgery Specialties, Psychiatry Unit of the University Hospital “Policlinico-Vittorio Emanuele” of Catania, University of Catania, Via S. Sofia 78, 95100 Catania (Sicily), Italy
- Rina Giuseppa Russo, Department of Medical and Surgery Specialties, Psychiatry Unit of the University Hospital “Policlinico-Vittorio Emanuele” of Catania, University of Catania, Via S. Sofia 78, 95100 Catania (Sicily), Italy
- Maria Luca, Department of Medical and Surgery Specialties, Psychiatry Unit of the University Hospital “Policlinico-Vittorio Emanuele” of Catania, University of Catania, Via S. Sofia 78, 95100 Catania (Sicily), Italy
- Journal Psychiatric Quarterly
- Online ISSN 1573-6709
- Print ISSN 0033-2720