Although ambiguity aversion has been found to impede the process and outcome of career decision‐making, knowledge regarding the association between personality characteristics and ambiguity aversion is limited. Thus, the author examined the prediction of the Big Five personality traits for ambiguity aversion and the mediation of tolerance and confidence in ambiguity management. The results obtained with a U.S. sample (N = 239) revealed the following: (a) neuroticism positively predicted ambiguity aversion; (b) extraversion did not predict ambiguity aversion; (c) agreeableness, conscientiousness, and openness negatively predicted ambiguity aversion; and (d) confidence in ambiguity management mediated the relationships between agreeableness, neuroticism, and openness and ambiguity aversion. These findings highlight the differential roles of the Big Five personality traits in ambiguity management and the importance of confidence in ambiguity management. The theoretical and practical implications of this study are discussed along with the study’s limitations and suggestions for future research.