Publication date: September 2019
Source: Ageing Research Reviews, Volume 54
Author(s): Annie Suh, Anthony Pham, Mikel Jean Cress, Thais Pincelli, Sarvam P. TerKonda, Alison J. Bruce, Abba C. Zubair, Joy Wolfram, Shane A. Shapiro
Abstract
Cellular and cell-derived components of adipose-derived tissue for the purposes of dermatologic and aesthetic rejuvenation applications have become increasingly studied and integrated into clinical practice. These components include micro-fragmented fat (nanofat), the stromal vascular fraction (SVF), adipose-derived mesenchymal stem cells (ASC), and extracellular vesicles (EVs), which have all shown capability to repair, regenerate, and rejuvenate surrounding tissue. Various aesthetic applications including hair growth, scar reduction, skin ischemia-reperfusion recovery, and facial rejuvenation are reviewed. In particular, results from preclinical and clinical studies are discussed, with a focus on clarification of nomenclature.