Problem-solving education to prevent depression among low-income mothers of preterm infants: a randomized controlled pilot trial

We sought to assess the feasibility and document key study processes of a problem-solving intervention to prevent depression
among low-income mothers of preterm infants. A randomized controlled pilot trial (n = 50) of problem-solving education (PSE) was conducted. We assessed intervention provider training and fidelity; recruitment
and retention of subjects; intervention acceptability; and investigators’ ability to conduct monthly outcome assessments,
from which we could obtain empirical estimates of depression symptoms, stress, and functioning over 6 months. Four of four
bachelor-level providers were able to deliver PSE appropriately with standardized subjects within 4 weeks of training. Of
12 randomly audited PSE sessions with actual subjects, all met treatment fidelity criteria. Nineteen of 25 PSE subjects (76%)
received full four-session courses; no subjects reported negative experiences with PSE. Eighty-eight percent of scheduled
follow-up assessments were completed. Forty-four percent of control group mothers experienced an episode of moderately severe
depression symptoms over the follow-up period, compared to 24% of PSE mothers. Control mothers experienced an average 1.19
symptomatic episodes over the 6 months of follow-up, compared to 0.52 among PSE mothers. PSE appears feasible and may be a
promising strategy to prevent depression among mothers of preterm infants.