There is limited practical and behavioral guidance for cultural humility in response to racially charged patient material in clinical practice. Although general principles exist, these are often vague and fail to provide the nuanced, objective understanding required for clinical responses that address both diversity and therapeutic needs. The goal of this article is to contribute toward what we perceive as a clinical and supervision training gap in cultural humility. We present a framework for understanding and delivering culturally humble and therapeutically effective responses. Using the deliberate practice multicultural orientation framework video prompts, we provide clinical responses to standardized behavioral patient vignettes to illustrate a framework that is both culturally humble and therapeutically meaningful. Using videos of patients from diverse backgrounds and varying experiences of discrimination, through four graded clinical responses, we illustrate a framework that combines cultural humility and therapeutic effectiveness. We comment on a variety of responses that characterize such principles in practice. This work fills an important gap in the clinical practice and training of cultural humility, especially in recent times of racial unrest. (PsycInfo Database Record (c) 2022 APA, all rights reserved)