The Guidelines for Psychological Practice with Lesbian, Gay, and Bisexual Clients were adopted by the APA Council of Representatives, February 18-20, 2011 and replace the original Guidelines for Psychotherapy with Lesbian, Gay, and Bisexual Clients adopted by the Council, February 26, 2000, and which expired at the end of 2010. Each of the 21 new guidelines provide an update of the psychological literature supporting them, include a section on “Rationale” and “Application,” and expand upon the original guidelines to provide assistance to psychologists in areas such as religion and spirituality, the differentiation of gender identity and sexual orientation, socioeconomic and workplace issues, and the use and dissemination of research on LGB issues. The guidelines are intended to inform the practice of psychologists and to provide information for the education and training of psychologists regarding LGB issues.