Throughout 2012, the U.S. Department of Health and Human Services (HHS) continued to make significant strides in implementing the National HIV/AIDS Strategy (NHAS). Working independently on some activities and collaboratively on many others, HHS operating divisions and offices were actively engaged in a wide variety of pursuits—from research, regulation, and policy making to training, public awareness, and grant making—that helped advance us toward the Strategy’s goals. This progress report, prepared by the Office of HIV/AIDS and Infectious Disease Policy (OHAIDP) with input from HHS agencies and offices, highlights some of the Department’s key accomplishments during calendar year 2012. It is, however, just a sampling of the myriad actions taken by the HHS operating divisions and staff offices to pursue the Strategy’s vision and goals.