This report highlights the key challenges facing the EU10 as a result of the high number of health professionals leaving to work abroad, focusing on specific problems and identifying topics for further research. A thorough analysis of the consequences is critical, since it appears the inflow of third-country nationals or return migration would not make up the shortfall caused by the outflow. However, as this is not equally true for all the countries, the report presents a differentiated picture between the countries concerned. The study draws on the results of two European research projects: Mobility of Health Professionals (MoHProf) and the Health Professional Mobility in the European Union Study (PROMeTHEUS).