The social determinants of health search identified 31 high quality reviews, 17 of which reported on outcomes relevant to this review. Outcomes reported on most frequently included: health care utilization (N=10), mental health (N=9), physical health (N=6), and behavioural problems (N=6). The participants studied ranged from the general population with low literacy to adults with mental disorders and homeless persons, as well as children, adults, and health professionals. The interventions evaluated can be classified into the following categories: improving health, supportive housing, home visiting/social support programs, improving literacy, after-school programs, gang/violence prevention, monetary incentives, reducing disparities, and the prevention of sexually transmitted infections.