How can programs advance the self-sufficiency and well-being of at-risk youth? This report attempts to answer this important question by presenting a research-based framework for efforts to help at-risk youth enter a career workforce trajectory and prepare to become well-functioning, self-sufficient adults. The framework presented is particularly relevant for youth who are or could be served by ACF programs—especially homeless youth, youth in the foster care system, and teen parents—but it may also apply to other programs. The framework suggests the possibility of using evidence-informed interventions to address two primary areas: youths’ resilience and human capital development. It suggests finding tailored solutions grounded in a trusting relationship between youth and program staff to help move youth toward both healthy functioning and economic self-sufficiency as they transition to adulthood. This report was written as part of the Youth Demonstration Development project being conducted by Mathematica Policy Research and Chapin Hall Center for Children.