This article reports on the effectiveness of an intensive quit-smoking intervention aimed at pregnant Indigenous women. Participants were recruited from antenatal clinics in Queensland and Western Australia between 2005 and 2008, and assigned to either usual care or to an intensive program featuring tailored advice and the engagement of partners and friends. Smoking rates of the 263 participants were followed up just prior to childbirth. This article discusses the findings and highlights some of the difficulties of undertaking research in this field.