SCIE has a commitment to producing rigorous, high-quality knowledge products. Central in this process is the systematic research review, which combines different types of research knowledge about a social care related topic, drawing on evidence of effectiveness, the views of users and providers, and organisational issues. This guidance updates and clarifies SCIE’s expectations, updating the original guidance (2006). It also introduces SCIE’s new approach to assessing the economic impact of social care practices. The guidelines provide a comprehensive guide to the conduct of SCIE research reviews, and are organised to describe processes which may also support other products.