Editor-in-chief Howard J. Shaffer asked contributors to consider their areas of interest with respect to the addiction syndrome model. In addition, to advance the conceptual framework that guides addiction research and treatment, contributors were asked to provide evidence to support or refute the addiction syndrome model. Dr. Shaffer hopes this approach will stimulate an enthusiastic dialogue that can advance the field by revising and improving the etiological models that provide the guiding wisdom about addiction and its causes and consequences.