The Closing the Gap Clearinghouse was established by the Council of Australian Governments (COAG) to bring together evidence-based research on overcoming disadvantage for Indigenous Australians. This paper focuses on three of the seven COAG building blocks that were the focus of the Clearinghouse in Year 2: early childhood; healthy homes; and governance and leadership. It provides policy makers with key findings about what works, what doesn’t, and gaps in the evidence.