Objective: To provide a quantitative assessment of the literature examining the cross-sectional association between loneliness and depressive symptoms in children and adolescents. Method: A total of 44 studies from 35 articles (n = 27, 214; mean age 13.63 years; 51% female) met inclusion criteria. Results: A medium, positive correlation between loneliness and depressive symptoms in children and adolescents was found (r = .48). Age and gender did not moderate the relationship between loneliness and depressive symptoms. Conclusion: Loneliness may be a particular risk factor for depression. These results have implications for COVID-19 disease containment measures.