New York University Caregiver Intervention (NYUCI) is a counseling and support intervention for spouse caregivers that is intended to improve the well-being of caregivers and delay the nursing home placement of patients with Alzheimer’s disease. The program also aims to help spouse caregivers mobilize their social support network and help them better adapt to their caregiving role. The program consists of four components, the first two of which are delivered within 4 months of enrollment in the study: (1) two individual counseling sessions of 1 to 3 hours tailored to each caregiver’s specific situation, (2) four family counseling sessions with the primary caregiver and family members selected by that caregiver, (3) encouragement to participate in weekly, locally available support groups after participation in the intervention, and (4) ad hoc counseling, counseling provided by telephone to caregivers and families whenever needed to help them deal with crises and the changing nature of their relative’s symptoms. The program is delivered by counselors with advanced degrees in social work or allied professions.