Drinker’s Check-up (DCU) is a computer-based brief intervention designed to help problem drinkers reduce their alcohol use and alcohol-related consequences. The program targets individuals along the continuum of problem drinking from hazardous use (e.g., binge-drinking college students) to alcohol dependence (e.g., individuals presenting for specialized alcohol treatment). DCU is based on the principles of brief motivational interviewing and is sensitive to the individual’s readiness to change. DCU’s core elements are characterized by the acronym FRAMES: Feedback is personalized, Responsibility for changing is left with the individual, Advice to change is given, a Menu of options for changing is offered, information is provided in an Empathetic style, and Self-efficacy is emphasized. The program consists of integrated assessment, feedback, and decisionmaking modules. Following the completion of the assessment and feedback modules, users are prompted to review information and exit the program, complete a second decisional balance exercise, or negotiate goals and develop a plan for change, depending on the individual’s reported readiness to change. DCU is available as a Windows program for use by health care providers, therapists, and treatment programs and as a Web application for use by the general public. The Windows version includes a companion Follow-up DCU (FDCU) program for conducting follow-up data collection and evaluating treatment outcomes. DCU can be used as a stand-alone intervention or as a precursor to more intensive alcohol treatment.