The qualitative research project described here was designed to gather opinions and insight from American Indian and Alaska Native (AI/AN) parents about “keeping babies healthy and safe” and effective messages and communication channels for information on these topics. The project took place in four urban communities nationwide. In this report we describe the results obtained from focus groups and individual discussions, which will be used in the development of a communications campaign to address high rates of infant mortality among AI/ANs in urban areas and beyond.