The manual describes treatment for people with both substance use and mental disorders. Clinical supervisors can use it in inservice training settings. Participants will become familiar with the evidence-based knowledge presented in TIP 42 and learn how to apply that knowledge in their treatment practices. The manual consists of 18 modules and includes presentation instructions, PowerPoint slides (that can be copied onto overhead transparencies), trainer scripts, and participant handouts. The training approach includes presentations, discussion sessions, and practice exercises for participants.