Nature Mental Health, Published online: 06 May 2026; doi:10.1038/s44220-026-00620-w
Psychotropic medication use, unhealthy lifestyle behaviors and polygenic risk for high body mass index (PGS-BMI) may elevate cardiovascular disease (CVD) risk in individuals with mental illness. In this study, the authors analyze UK Biobank data, revealing that psychotropic users with high PGS-BMI and unhealthy lifestyles face the greatest BMI and CVD risk, highlighting the need for targeted interventions.