The Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) Research Consortium recommends a 3-pronged approach to treatment of children with PANS that includes concurrent psychiatric and behavioral interventions, immunomodulatory treatments, and infectious disease treatments.1 A comprehensive and balanced treatment plan must address all 3 areas of intervention. Psychiatric treatment with medications, primarily selective serotonin reuptake inhibitors and therapy (cognitive-behavioral therapy for children and parent management training for caretakers) are well-described in the American Academy of Pediatrics (AAP) PANS Clinical Report.2 However, discussion and recommendations for assessment and management of immune dysregulation and infections are limited.