The global public health community is facing a new era of uncertainty. As the USA embarks on another political shift, the risks to global health initiatives, scientific collaboration, and evidence-based policymaking are mounting. The lessons of the past teach us that public health can be an easy target in times of political upheaval, particularly when misinformation and disinformation infiltrate public discourse. As Professor Martin McKee from EUPHA warns, “disinformation is the new normal with far-reaching implications for society, including population health.” The scientific community must be proactive, not reactive, in confronting these challenges. Our tools—science, advocacy, and capacity building—are necessary but insufficient. Public health must also embrace innovation across multiple domains while remaining connected to our core principles of equity and sustainability.