High uptake of vaccination against mpox in men who have sex with men (MSM) on HIV pre-exposure prophylaxis (PrEP) in Paris, France

In July 2022, the French health authorities recommended smallpox vaccination (IMVANEX and JYNNEOS) to prevent mpox in population at high risk of exposure. HIV and pre-exposure prophylaxis (PrEP) physicians were informed and involved in the deployment of this vaccination, but there has been no communication to the general public. The current mpox epidemic in France, the rest of Europe and the USA is concentrated among men who have sex with men (MSM), particularly in case of multiple physical and sexual contacts.1 2 Several case series have reported high proportions of people living with HIV and of users of HIV–PrEP.3 4

To assess the uptake of vaccination among PrEP users, we conducted an observational study in two centres in Paris, France (Infectious Diseases department of the Pitié-Salpêtrière hospital and ‘Le 190’ sexual health clinic). We systematically asked PrEP users who attended a routine check-up…

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