Young people with disabilities (YPWDs) in higher education require tailored career support in finding employment. Seventy-five YPWDs in Hong Kong participated in a quantitative program effectiveness study using a three-group comparison design (experimental, other intern, and control) to improve career-related outcomes. Generalized estimating equations revealed that the experimental group showed significant improvements in career-related outcomes such as career decision self-efficacy and focused job search strategy while increasing disability-related outcomes and work cynicism. This study reveals the impact of disability on work experience and its benefits for YPWDs. Important policy implications for future school–work transition programs for YPWDs are discussed.